Research Articles
How Bone Marrow Creates a Safe Haven for Leukemia Cells
Discover how bone marrow stromal cells protect chronic lymphocytic leukemia cells through HES1 regulation and H3K27me3 demethylation mechanisms.
Marine Marvel: How a Sea Sponge Compound Fights Leukemia at the Molecular Level
Discover how dideoxypetrosynol A from marine sponges fights leukemia through cell cycle arrest and apoptosis mechanisms.
Breaking the Code: How Two Drugs Team Up to Fight Leukemia
Discover how BIBR1532 and arsenic trioxide work synergistically to combat acute promyelocytic leukemia through targeted molecular mechanisms.
The Cellular Civil War: How Cancer Cells Survive or Surrender to Treatment
Explore the fascinating microscopic battle between chemosensitive and chemoresistant leukemic cells when exposed to drug therapy, and discover how scientists measure proliferation, apoptosis, and necrosis.
A One-Two Punch Against Leukemia: How Scientists Are Outsmarting Drug-Resistant Cancer Cells
Discover how PI3K inhibitors combined with STI571 create a powerful synergistic effect against drug-resistant leukemia cells in this engaging scientific exploration.
How a Diabetes Drug Could Revolutionize Leukemia Treatment: The AMPK-RUNX1-STAT3 Connection
Discover how metformin-induced AMPK phosphorylation of RUNX1 inhibits STAT3 and overcomes imatinib resistance in chronic myelogenous leukemia (CML).
Breaking the Shield: How SYK Inhibition Overcomes Drug Resistance in Leukemia Treatment
Discover how SYK inhibition effectively overcomes MCL-1 mediated ABT-199 resistance in CLL cells compared to BTK or PI3Kδ inhibition.
Breaking the Shield: How a Novel Small Molecule AP030 Fights Leukemia by Targeting GCN2
Discover how the novel small molecule AP030 targets GCN2 to combat acute leukemia by disrupting cancer cell survival mechanisms in nutrient-starved environments.
Turning Down the pH: A New Strategy to Combat Resistant Leukemia
Discover how targeting intracellular pH regulation offers a novel approach to overcome drug resistance in FLT3/ITD mutated acute myeloid leukemia (AML).
A Borrowed Key: Can a Miracle Drug for One Leukemia Unlock Cures for Others?
Exploring the potential of retinoic acid in treating non-APL Acute Myeloid Leukemia through differentiation therapy and combination treatments.