Research Articles
How Stopping a Single Enzyme Could Protect Your Heart From Stress Damage
Discover how pharmacological inhibition of adipose tissue ATGL by Atglistatin prevents catecholamine-induced myocardial damage and protects heart health.
The Leaky Vessel: Unraveling the Mystery of Systemic Capillary Leak Syndrome
Exploring the pathogenesis, genetic factors, and treatment approaches for Systemic Capillary Leak Syndrome (SCLS), a rare vascular disorder.
Beyond Conventional Treatment: How Targeted Intra-arterial Chemotherapy Fights Endometrial Cancer
Explore how neoadjuvant intra-arterial infusion chemotherapy influences apoptosis and multidrug resistance in endometrial cancer through targeted molecular mechanisms.
The Kidney's Rescue Squad: How a Genetic Maestro Revives Cellular Cleanup After Injury
Discover how the SP1 protein and autophagy work together to protect kidneys from ischemia-reperfusion injury through the miR-205/PTEN/Akt pathway.
LRRK2 and the Chain Reaction: How a Single Protein Links Inflammation and Iron Death in Parkinson's Disease
Explore how LRRK2 mediates α-synuclein-induced neuroinflammation and ferroptosis through the p62-Keap1-Nrf2 pathway in Parkinson's Disease.
The Bcl-2 Enigma: Understanding the Protein That Lets Ovarian Tumors Survive
Explore the role of Bcl-2 protein in ovarian cancer development, progression, and treatment. Understand the paradoxical findings and therapeutic implications.
Unlocking Autism's Origins: How a Brief Signal Disruption in the Infant Brain Causes Lasting Changes
Discover how transient blockade of ERK phosphorylation during critical developmental periods causes autistic phenotypes in mice, revealing insights into autism spectrum disorder mechanisms.
The Unheard Side Effect: How a Common Chemotherapy Drug Damages Our Ears
Discover how Cisplatin chemotherapy causes permanent hearing loss and the groundbreaking research challenging long-held theories about its mechanism of action.
The Epigenetic Casualty: How Diabetes Destroys a Key Gene Regulator in Insulin-Producing Cells
Discover how diabetes triggers proteasomal degradation of p300, a crucial epigenetic regulator in pancreatic beta-cells, leading to impaired insulin production and cell death.
The Double-Edged Sword of Nanotechnology: How Carbon Nanotubes Can Harm Lungs
Exploring how carbon nanotubes trigger inflammation, tissue death, and scarring in lungs, and what this means for nanotechnology safety.