Research Articles
TUNEL Assay for DNA Fragmentation: A Comprehensive Guide to Detecting Late-Stage Apoptosis
This article provides a comprehensive resource for researchers and drug development professionals on the TUNEL assay, a cornerstone technique for detecting DNA fragmentation during late-stage apoptosis.
Detecting Cytochrome c Release: A Comprehensive Guide to Apoptosis Assays
The release of cytochrome c from the mitochondria is a definitive, point-of-no-return event in the intrinsic apoptotic pathway, serving as a critical biomarker for basic research and drug development.
A Complete Guide to Annexin V Staining: Optimized Protocol for Early Apoptosis Detection in Research and Drug Development
This comprehensive guide provides researchers, scientists, and drug development professionals with a complete framework for implementing Annexin V staining to detect early apoptosis.
Activating Extrinsic Apoptosis via the Fas Receptor: A Comprehensive Protocol from Mechanism to Therapeutic Application
This article provides a comprehensive guide for researchers and drug development professionals on activating and analyzing the Fas-mediated extrinsic apoptosis pathway.
MOMP: Mitochondrial Outer Membrane Permeabilization in Apoptosis - Mechanisms, Analysis, and Therapeutic Targeting
This article provides a comprehensive analysis of mitochondrial outer membrane permeabilization (MOMP), a pivotal event in the intrinsic apoptotic pathway.
A Practical Guide to Inducing and Analyzing Intrinsic Apoptosis in Cell Culture
This article provides a comprehensive guide for researchers and drug development professionals on inducing and validating intrinsic apoptosis in cell culture models.
Death Receptors in Extrinsic Apoptosis: Molecular Mechanisms, Research Tools, and Therapeutic Targeting in Cancer
This article provides a comprehensive overview of the extrinsic apoptosis pathway, with a focused examination of death receptors as critical regulators of programmed cell death.
The BCL-2 Protein Family: Master Regulators of Intrinsic Apoptosis in Health and Targeted Therapy
This article provides a comprehensive analysis of the BCL-2 protein family's critical role as the central regulator of intrinsic apoptosis.
Intrinsic vs. Extrinsic Apoptosis: Molecular Mechanisms, Caspase Activation Pathways, and Therapeutic Implications
This article provides a comprehensive analysis of the molecular mechanisms governing caspase activation in the intrinsic (mitochondrial) and extrinsic (death receptor) apoptosis pathways.
Cellular Stress and Intrinsic Apoptosis: Molecular Triggers, Detection Methods, and Therapeutic Applications
This article provides a comprehensive analysis of the diverse cellular stressors that activate the intrinsic apoptotic pathway, a crucial mechanism for maintaining tissue homeostasis and a key target in disease...