Research Articles
Annexin V Staining Flow Cytometry Protocol: A Complete Guide for Apoptosis Detection
This comprehensive guide provides researchers, scientists, and drug development professionals with a complete framework for planning, executing, and validating Annexin V staining experiments for apoptosis detection via flow cytometry.
Mastering the TUNEL Assay: A Complete Protocol and Troubleshooting Guide for Tissue Sections
This article provides a comprehensive guide to the Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, a cornerstone technique for detecting DNA fragmentation associated with cell death in tissue...
Apoptosis in MODS: Molecular Mechanisms, Biomarker Discovery, and Emerging Therapeutic Strategies
Multiple organ dysfunction syndrome (MODS) remains a leading cause of mortality in critically ill patients, with apoptosis occupying a central role in its pathogenesis.
Apoptosis: The Master Regulator of Tissue Homeostasis, Development, and Disease
This article provides a comprehensive exploration of apoptosis, or programmed cell death, a fundamental process critical for embryonic development, tissue homeostasis, and immune function.
Caspase Cascade Activation and Executioner Functions: Mechanisms, Regulation, and Therapeutic Targeting
This article provides a comprehensive exploration of the caspase cascade, a cornerstone of programmed cell death (apoptosis) and inflammation.
Cytochrome c Release in Intrinsic Apoptosis: Molecular Mechanisms, Regulation, and Therapeutic Implications
This article provides a comprehensive analysis of the cytochrome c release mechanism within the intrinsic apoptotic pathway, tailored for researchers, scientists, and drug development professionals.
A Comprehensive Guide to the Morphological Features of Apoptosis Phases I, IIa, and IIb
This article provides a detailed examination of the distinct morphological characteristics that define Phase I (early), Phase IIa (middle), and Phase IIb (late) of apoptosis.
Targeting Apoptotic Dysregulation in Cancer: From Molecular Mechanisms to Clinical Therapeutics
This comprehensive review explores the critical role of apoptosis modulators in cancer pathogenesis and treatment.
p53 as the Master Regulator of Programmed Cell Death: From Molecular Mechanisms to Targeted Cancer Therapies
This article provides a comprehensive analysis of the p53 tumor suppressor pathway and its central role in regulating diverse programmed cell death (PCD) mechanisms, including apoptosis, ferroptosis, necroptosis, and pyroptosis.
Bcl-2 and Bcl-xL: Masters of Cell Survival from Apoptosis Mechanisms to Targeted Cancer Therapy
This article provides a comprehensive analysis of the Bcl-2 protein family, focusing on the pivotal roles of Bcl-2 and Bcl-xL as key regulators of the intrinsic apoptosis pathway.