Research Articles
A Step-by-Step Guide to Apoptosis Detection in Primary Neurons Using CellEvent Caspase-3/7
This protocol provides a detailed methodology for detecting apoptosis in primary cortical neurons using the CellEvent Caspase-3/7 reagent, optimized for high-content imaging and analysis.
Beyond DEVD: Unraveling Caspase-3 and Caspase-7 Specificity in Next-Generation Biosensors
This article provides a comprehensive analysis for researchers and drug development professionals on the critical challenge of distinguishing caspase-3 from caspase-7 using DEVD-based biosensors.
Real-Time Imaging of Caspase-3/7 Activation with the ZipGFP Reporter: A Guide for Biomedical Research and Drug Discovery
This article provides a comprehensive resource for researchers and drug development professionals on the ZipGFP-based fluorogenic reporter, a transformative tool for real-time imaging of executioner caspase activation.
Caspase-3 in Actin Cytoskeleton Remodeling: Unveiling Non-Apoptotic Roles in Cancer and Inflammation
This article synthesizes cutting-edge research revealing the multifaceted roles of caspase-3 beyond apoptosis, focusing on its direct regulation of actin cytoskeleton organization.
Structural Biology of Caspases: Decoding Initiator and Executioner Mechanisms for Therapeutic Development
This article provides a comprehensive analysis of the structural differences between initiator and executioner caspases, crucial proteases regulating cell death and inflammation.
Anastasis: Unraveling the Mechanisms of Cell Survival After Executioner Caspase Activation and Its Impact on Cancer Therapy
This article comprehensively examines anastasis, the process by which cells reverse apoptosis and survive after the activation of executioner caspases, a stage historically considered a point of no return in...
Beyond Cell Death: The Emerging Role of Caspase-3 in Cancer Cell Motility and Metastasis
This article synthesizes current research revealing the non-apoptotic functions of caspase-3, specifically its critical role in regulating cell motility, migration, and invasion in cancer.
CASP9 Gene Polymorphisms and Cancer Susceptibility: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications
This comprehensive review synthesizes current evidence on the pivotal role of Caspase-9 (CASP9) gene polymorphisms in modulating cancer susceptibility.
Phosphorylation Control of Caspase Cascades: Molecular Mechanisms and Therapeutic Implications
This article provides a comprehensive analysis of phosphorylation as a central mechanism regulating caspase cascade activity, a crucial process in programmed cell death and cellular homeostasis.
Mitochondrial Cytochrome c Release: Unraveling the Core Trigger of Intrinsic Apoptosis in Disease and Therapy
This comprehensive review delves into the mitochondrial intrinsic apoptosis pathway, with a focused examination of cytochrome c release as a pivotal regulatory point.