Research Articles
Apoptosis: The Master Regulator of Tissue Homeostasis, Development, and Disease
This article provides a comprehensive exploration of apoptosis, or programmed cell death, a fundamental process critical for embryonic development, tissue homeostasis, and immune function.
Caspase Cascade Activation and Executioner Functions: Mechanisms, Regulation, and Therapeutic Targeting
This article provides a comprehensive exploration of the caspase cascade, a cornerstone of programmed cell death (apoptosis) and inflammation.
Cytochrome c Release in Intrinsic Apoptosis: Molecular Mechanisms, Regulation, and Therapeutic Implications
This article provides a comprehensive analysis of the cytochrome c release mechanism within the intrinsic apoptotic pathway, tailored for researchers, scientists, and drug development professionals.
A Comprehensive Guide to the Morphological Features of Apoptosis Phases I, IIa, and IIb
This article provides a detailed examination of the distinct morphological characteristics that define Phase I (early), Phase IIa (middle), and Phase IIb (late) of apoptosis.
Targeting Apoptotic Dysregulation in Cancer: From Molecular Mechanisms to Clinical Therapeutics
This comprehensive review explores the critical role of apoptosis modulators in cancer pathogenesis and treatment.
p53 as the Master Regulator of Programmed Cell Death: From Molecular Mechanisms to Targeted Cancer Therapies
This article provides a comprehensive analysis of the p53 tumor suppressor pathway and its central role in regulating diverse programmed cell death (PCD) mechanisms, including apoptosis, ferroptosis, necroptosis, and pyroptosis.
Bcl-2 and Bcl-xL: Masters of Cell Survival from Apoptosis Mechanisms to Targeted Cancer Therapy
This article provides a comprehensive analysis of the Bcl-2 protein family, focusing on the pivotal roles of Bcl-2 and Bcl-xL as key regulators of the intrinsic apoptosis pathway.
Apoptosis-Related Genes (ARGs): A Comprehensive Guide to Functions, Analysis, and Therapeutic Targets
This article provides a comprehensive resource for researchers, scientists, and drug development professionals on Apoptosis-Related Genes (ARGs). It covers the foundational biology of key ARG families—including caspases, the Bcl-2 family, and p53—and their roles in intrinsic and extrinsic apoptotic pathways. The content extends to modern methodologies for ARG identification and analysis, common challenges in research, and the critical validation of ARGs as therapeutic targets in diseases like cancer. By synthesizing established knowledge with current research and clinical applications, this guide aims to bridge the gap between basic science and the development of novel apoptosis-targeting therapies.
Unlocking a Cellular Brake: How a Tiny Molecule Could Halt Stomach Cancer
Discover how microRNA miR-1287-5p suppresses gastric cancer by targeting LAMTOR3 protein, potentially leading to new cancer therapies.
The Blue Hope: How a Marine Algae Pigment Could Revolutionize Cancer Treatment
Discover how marennine, a blue-green pigment from marine diatoms, shows promising anti-cancer effects by inhibiting tumor cell proliferation and angiogenesis.