Research Articles
Advanced SDS-PAGE Strategies for Resolving PARP-1 Fragments and Post-Translational Modifications
This methodological guide provides researchers and drug development professionals with optimized SDS-PAGE protocols for effective separation and analysis of PARP-1 fragments and their complex post-translational modifications.
A Complete Guide to Preparing Cell Lysates for PARP-1 Cleavage Western Blot
This guide provides a comprehensive, step-by-step protocol for researchers and drug development professionals to successfully prepare cell lysates for detecting PARP-1 cleavage via western blot, a key marker of apoptosis.
A Step-by-Step Western Blot Protocol to Detect PARP-1 Cleavage as a Key Apoptosis Marker
This article provides a comprehensive guide for researchers and drug development professionals on using western blotting to detect PARP-1 cleavage, a established hallmark of apoptosis.
Ultimate Guide to Selecting the Best Cleaved PARP-1 Antibodies for Western Blot Analysis
This article provides a comprehensive resource for researchers and drug development professionals seeking to accurately detect cleaved PARP-1, a crucial apoptosis marker, via Western blot.
PARP-1 Cleavage Fragments: From Molecular Hallmarks to Therapeutic Targets in Neurodegeneration
This article synthesizes current knowledge on the proteolytic cleavage of PARP-1, a key DNA damage sensor, and the distinct biological activities of its resulting fragments in the context of neurodegenerative...
PARP-1 Cleavage: A Critical Switch Between Cell Death Pathways in Health and Disease
This article provides a comprehensive analysis of the mechanisms and functional consequences of poly(ADP-ribose) polymerase-1 (PARP-1) cleavage during programmed cell death (PCD).
Beyond Apoptosis: PARP-1 Cleavage as a Central Switch in Caspase-Dependent and Caspase-Independent Cell Death Pathways
This article synthesizes current knowledge on the proteolytic cleavage of PARP-1, a pivotal event in cellular fate decisions.
PARP-1 Cleavage: Molecular Mechanisms and Therapeutic Consequences in DNA Repair Inactivation
This article provides a comprehensive analysis of how PARP-1 cleavage serves as a critical molecular switch that inactivates DNA repair pathways.
PARP-1 Cleavage: From Apoptotic Hallmark to Therapeutic Target in Disease and Drug Development
This article provides a comprehensive analysis of poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, a established biochemical hallmark of apoptosis.
Beyond the Full-Length Enzyme: The Pro-Apoptotic Functions and Therapeutic Potential of Truncated PARP-1 Fragments
This review synthesizes current knowledge on the biological functions of truncated PARP-1 (tPARP1) fragments in cell death pathways.