Research Articles
Strategies to Reduce Background Fluorescence in Caspase FRET Reporters: A Guide for Enhanced Signal Detection in Live-Cell Imaging
This article provides a comprehensive guide for researchers and drug development professionals on minimizing background fluorescence in caspase FRET reporters, a critical challenge in apoptosis and cell death studies.
Z-VAD-FMK: Mechanism, Applications, and Future Directions in Caspase Inhibition Research
This article provides a comprehensive analysis of Z-VAD-FMK, a pan-caspase inhibitor that has become an indispensable tool in cell death research.
Incomplete Caspase-9 Activation: Decoding Apoptosome Formation Failures in Disease and Therapy
This article provides a comprehensive analysis of the molecular mechanisms and pathological consequences of incomplete caspase-9 activation due to impaired apoptosome formation.
Real-Time Caspase Activity Monitoring in 3D Organoids: A Guide for Advanced Drug Discovery and Disease Modeling
This article provides a comprehensive resource for researchers and drug development professionals on monitoring caspase activity in 3D organoid models.
Calreticulin Exposure and Caspase Activation: Orchestrating Immunogenic Cell Death in Cancer Therapy
This article explores the critical interplay between caspase activation and calreticulin (CALR) exposure in eliciting immunogenic cell death (ICD), a regulated cell death that stimulates antitumor immunity.
Live-Cell Insights: Measuring Caspase-Dependent Cell Migration with IncuCyte Technology
This article explores the innovative application of Incucyte® Live-Cell Analysis Systems for investigating caspase-dependent cell migration, a non-apoptotic function of caspases with significant implications in cancer metastasis.
Live-Cell Tracking of Apoptosis-Induced Proliferation (AiP): Mechanisms, Imaging, and Therapeutic Implications
This article provides a comprehensive overview of live-cell tracking technologies for studying Apoptosis-Induced Proliferation (AiP), a paradoxical process where dying cells stimulate division in their neighbors.
Simultaneous Detection of Caspase-8 and Caspase-3 Activity with AIEgens: A Guide for Advanced Apoptosis Imaging
This article provides a comprehensive resource for researchers and drug development professionals on the simultaneous detection of caspase-8 and caspase-3 activity using aggregation-induced emission fluorogens (AIEgens).
Flow Cytometry Analysis of Caspase Activation and Annexin V: A Comprehensive Guide for Apoptosis Detection
This article provides a comprehensive guide for researchers and drug development professionals on using flow cytometry to detect apoptosis through caspase activation and Annexin V staining.
A Step-by-Step Guide to Apoptosis Detection in Primary Neurons Using CellEvent Caspase-3/7
This protocol provides a detailed methodology for detecting apoptosis in primary cortical neurons using the CellEvent Caspase-3/7 reagent, optimized for high-content imaging and analysis.